Alcohol drinking phenotypes

Question 1: AUDIT-C

  • Original variable: baseusein30alc
  • Description: Alcohol use frequency standardized to days of use in the last 30
  • Coding: 0=never, 1=monthly or less, 3=2-4 times a month, 10=2-3 times/wk, 20=4+ times/wk
  • New variable: base30alc_drinkers3c
  • Recoding: 1=monthly or less, 2=2-4 times a month, 3=2+ times/wk
  • Inclusion/exclusion: filter(baseusein30alc>0)

MR-MEGA results

AFR results

AMR results

EUR results

Literature

Literature findings Liu et al. Nature 2019 for drinks per week
Genes: ADH1B, GCKR, SLC39A8, SERPINA1, ACTR1B, TNFSF12-13, HGFAC, BDNF, ZNF789

Question 2: AUDIT-C

  • Original variable: basealc2
  • Description: How many drinks containing alcohol do you have on a typical day when you are drinking?
  • Coding: 0=1-2 drinks, 1=3-4 drinks, 2=5-6 drinks, 3=7-8 drinks, 4=9+ drinks
  • New variable: basealc2_drinkers2c
  • Recoding: 0=1-2 drinks, 1=3+ drinks
  • Inclusion/exclusion: filter(baseusein30alc>0)

MR-MEGA results

AFR results

AMR results

EUR results

Literature

Literature findings Liu et al. Nature 2019 for drinks per week
Genes: ADH1B, GCKR, SLC39A8, SERPINA1, ACTR1B, TNFSF12-13, HGFAC, BDNF, ZNF789

Question 3: AUDIT-C

  • Original variable: baseusein30bin
  • Description: 5+ drinks on 1 occasion (binge drinking) frequency standardized to days of use in the last 30 days
  • Coding: 0=never, 1=monthly or less, 3=2-4 times a month, 10=2-3 times/wk, 20=4 or more times/wk
  • New variable: base30bin_drinkers2c
  • Recoding: 0=never, 1=more than never
  • Inclusion/exclusion: filter(baseusein30alc>0)

MR-MEGA results

AFR results

AMR results

EUR results

Literature

Literature findings Liu et al. Nature 2019 for drinks per week
Genes: ADH1B, GCKR, SLC39A8, SERPINA1, ACTR1B, TNFSF12-13, HGFAC, BDNF, ZNF789

Smoking/cigarette use

Smoking initiation

  • Original variable: basecig3c
  • Description: Cigarette use status
  • Coding: 0=never, 1=former, 2=current
  • New variable: SmkInit
  • Recoding: 0=never, 1=former/current
  • Inclusion/exclusion: N/A

MR-MEGA results

AFR results

AMR results

EUR results

Literature

Literature findings from Liu et al. for smoking initiation
Genes: REV3L, BDNF, RHOT2, ZNF789, BRWD1, ENTPD6, RPS6KA4, FAM163A, PRRC2B, ADAM15, MMS22L, QSER1, ACTR1B

Smoking Cessation

  • Original variable: basecig3c
  • Description: Cigarette use status
  • Coding: 0=never, 1=former, 2=current
  • New variable: SmkCess
  • Recoding: 0=current, 1=former
  • Inclusion/exclusion: remove basecig3c=0

MR-MEGA results

AFR results

AMR results

EUR results

Literature

Literature findings from Liu et al. for smoking cessation
Genes: CHRNA5

Cigarettes per day

  • Original variable: basecigintc
  • Description: cigarettes/day
  • Coding: 5=<1/2 pack/day, 15=1/2-1 pack/day, 30=1-2 packs/day, 41= >2 packs/day; 0=none, 3=1-5, 8=6-10, 13=11-15, 18=16-20, 25.5=21-30, 31= >30
  • New variable: Cigperday2c
  • Recoding: 0= <15 cigarettes/day, 1= 15+ cigarettes/day
  • Inclusion/exclusion: remove basecig3c=0

MR-MEGA results

AFR results

AMR results

EUR results

Literature

Literature findings from Liu et al. for cigarettes per day
Genes: CHRNA5, HIST1H2BE, GRK4

Marijuana use

Marijuana initiation

  • Original variable: basepot3c
  • Description: Marijuana use status
  • Coding: 0=never, 1=former, 2=current
  • New variable: PotInit
  • Recoding: 0=never, 1=former/current
  • Inclusion/exclusion: N/A

MR-MEGA results

AFR results

AMR results

EUR results

Literature

Literature findings from Stringer et al. Transl Psychiatry 2016 for cannabis use
Genes: CADM2, NCAM1

Marijuana Cessation

  • Original variable: basepot3c
  • Description: Marijuana use status
  • Coding: 0=never, 1=former, 2=current
  • New variable: PotCess
  • Recoding: 0=current, 1=former
  • Inclusion/exclusion: remove basepot3c=0

MR-MEGA results

AFR results

AMR results

EUR results

Literature

Literature findings from Stringer et al. Transl Psychiatry 2016 for cannabis use
Genes: CADM2, NCAM1

Frequency

  • Original variable: basepotper30
  • Description: Marijuana use frequency in the past 3 months standardized to days of use in the last 30
  • Coding: 0=never, 0.5=once or twice, 1=monthly, 4=weekly, 30=daily or almost daily
  • New variable: Potper30_2c
  • Recoding: 0=monthly or less, 4=More than monthly
  • Inclusion/exclusion: keep basepot3c=2

MR-MEGA results

AFR results

AMR results

EUR results

Literature

Literature findings from Stringer et al. Transl Psychiatry 2016 for cannabis use
Genes: CADM2, NCAM1