Alcohol drinking phenotypes
Question 1: AUDIT-C
- Original variable: baseusein30alc
- Description: Alcohol use frequency standardized to days of use in the last 30
- Coding: 0=never, 1=monthly or less, 3=2-4 times a month, 10=2-3 times/wk, 20=4+ times/wk
- New variable: base30alc_drinkers3c
- Recoding: 1=monthly or less, 2=2-4 times a month, 3=2+ times/wk
- Inclusion/exclusion: filter(baseusein30alc>0)
MR-MEGA results
AFR results
AMR results
EUR results
Literature
Literature findings Liu et al. Nature 2019 for drinks per week
Genes: ADH1B, GCKR, SLC39A8, SERPINA1, ACTR1B, TNFSF12-13, HGFAC, BDNF, ZNF789
Question 2: AUDIT-C
- Original variable: basealc2
- Description: How many drinks containing alcohol do you have on a typical day when you are drinking?
- Coding: 0=1-2 drinks, 1=3-4 drinks, 2=5-6 drinks, 3=7-8 drinks, 4=9+ drinks
- New variable: basealc2_drinkers2c
- Recoding: 0=1-2 drinks, 1=3+ drinks
- Inclusion/exclusion: filter(baseusein30alc>0)
MR-MEGA results
AFR results
AMR results
EUR results
Literature
Literature findings Liu et al. Nature 2019 for drinks per week
Genes: ADH1B, GCKR, SLC39A8, SERPINA1, ACTR1B, TNFSF12-13, HGFAC, BDNF, ZNF789
Question 3: AUDIT-C
- Original variable: baseusein30bin
- Description: 5+ drinks on 1 occasion (binge drinking) frequency standardized to days of use in the last 30 days
- Coding: 0=never, 1=monthly or less, 3=2-4 times a month, 10=2-3 times/wk, 20=4 or more times/wk
- New variable: base30bin_drinkers2c
- Recoding: 0=never, 1=more than never
- Inclusion/exclusion: filter(baseusein30alc>0)
MR-MEGA results
AFR results
AMR results
EUR results
Literature
Literature findings Liu et al. Nature 2019 for drinks per week
Genes: ADH1B, GCKR, SLC39A8, SERPINA1, ACTR1B, TNFSF12-13, HGFAC, BDNF, ZNF789
Smoking/cigarette use
Smoking initiation
- Original variable: basecig3c
- Description: Cigarette use status
- Coding: 0=never, 1=former, 2=current
- New variable: SmkInit
- Recoding: 0=never, 1=former/current
- Inclusion/exclusion: N/A
MR-MEGA results
AFR results
AMR results
EUR results
Literature
Literature findings from Liu et al. for smoking initiation
Genes: REV3L, BDNF, RHOT2, ZNF789, BRWD1, ENTPD6, RPS6KA4, FAM163A, PRRC2B, ADAM15, MMS22L, QSER1, ACTR1B
Smoking Cessation
- Original variable: basecig3c
- Description: Cigarette use status
- Coding: 0=never, 1=former, 2=current
- New variable: SmkCess
- Recoding: 0=current, 1=former
- Inclusion/exclusion: remove basecig3c=0
MR-MEGA results
AFR results
AMR results
EUR results
Literature
Literature findings from Liu et al. for smoking cessation
Genes: CHRNA5
Cigarettes per day
- Original variable: basecigintc
- Description: cigarettes/day
- Coding: 5=<1/2 pack/day, 15=1/2-1 pack/day, 30=1-2 packs/day, 41= >2 packs/day; 0=none, 3=1-5, 8=6-10, 13=11-15, 18=16-20, 25.5=21-30, 31= >30
- New variable: Cigperday2c
- Recoding: 0= <15 cigarettes/day, 1= 15+ cigarettes/day
- Inclusion/exclusion: remove basecig3c=0
MR-MEGA results
AFR results
AMR results
EUR results
Literature
Literature findings from Liu et al. for cigarettes per day
Genes: CHRNA5, HIST1H2BE, GRK4
Marijuana use
Marijuana initiation
- Original variable: basepot3c
- Description: Marijuana use status
- Coding: 0=never, 1=former, 2=current
- New variable: PotInit
- Recoding: 0=never, 1=former/current
- Inclusion/exclusion: N/A
MR-MEGA results
AFR results
AMR results
EUR results
Literature
Literature findings from Stringer et al. Transl Psychiatry 2016 for cannabis use
Genes: CADM2, NCAM1
Marijuana Cessation
- Original variable: basepot3c
- Description: Marijuana use status
- Coding: 0=never, 1=former, 2=current
- New variable: PotCess
- Recoding: 0=current, 1=former
- Inclusion/exclusion: remove basepot3c=0
MR-MEGA results
AFR results
AMR results
EUR results
Literature
Literature findings from Stringer et al. Transl Psychiatry 2016 for cannabis use
Genes: CADM2, NCAM1
Frequency
- Original variable: basepotper30
- Description: Marijuana use frequency in the past 3 months standardized to days of use in the last 30
- Coding: 0=never, 0.5=once or twice, 1=monthly, 4=weekly, 30=daily or almost daily
- New variable: Potper30_2c
- Recoding: 0=monthly or less, 4=More than monthly
- Inclusion/exclusion: keep basepot3c=2
MR-MEGA results
AFR results
AMR results
EUR results
Literature
Literature findings from Stringer et al. Transl Psychiatry 2016 for cannabis use
Genes: CADM2, NCAM1